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The aim of the stuty is to evaluate the effect of antihypertensive treatment with valsartan or lisinopril on sildenafil use in impotent hypertensive men. Thirty-eight mild to moderate (DBP 90 105 mmHg) hypertensive patients, aged 46-65 years, able to have an erection only with sildenafil, were studied. After a 4 week placebo period the patients were randomized to valsartan 160 mg od or to lisinopril 20 mg od for 16 weeks; then after a 4 week placebo period they were crossed to the alternative regimen for other 16 weeks according to a cross-over design. At the end of each placebo period and every 4 weeks during the active periods, BP was measured and the patients filled out in privacy a questionnaire addressing the use of sildenafil during the previous 4 weeks. The results are shown in the table. In conclusions both drugs induced a similar BP lowering; however only during the chronic treatment with valsartan the use of sildenafil significantly increased. It suggests that Angiotensin II antagonism induces an increase in sexual desire in impotent hypertensive men. It could be related to the reactive stimulation of Angiotensin cascade due to AT1 receptors blockade.

Different effect of valsartan and lisinopril on sildenafil use in hypertensive men with erectile dysfunction