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BackgroundThe tandem mass spectrometry method allows the processing of dry blood samples, and can be sent by regular mail, in order to detect several congenital abnormalities. In many countries these tests are routine practice. This article studies the possibility of establishing a nationwide universal coverage neonatal screening program.ObjectivesTo estimate the costs and resource use involved in a tandem mass spectrometry universal screening program, and to estimate the cost per detected case in Colombia.Materials and methodsA literature search was performed looking for the economic analysis for neonatal screening of phenylketonuria, galactosemia, biotinidase deficiency, congenital adrenal hyperplasia, medium chain acyl-CoA dehydrogenase deficiency, and organic acidemia. Costs are shown in US dollars (1 USD=1880 COP).ResultsThe costs of tandem mass spectrometry equipment were estimated between USD$ 373,000 and USD$ 585,000, with a monthly capacity of 4,000 tests and an eight-year useful life. The costs for supplies and transport of tests were USD$ 11.50 per test. If an initial productivity of 50% for 12 machines in the first year, 80% for the second, and 90% for the third, with a cost of USD$ 17.81 per test (including confirmatory test), and a 75% neonatal coverage is assumed, a positive balance would be reached in the second year, and the investment cost regained by the fourth year.ConclusionsBy screening 518,400 newborns annually, a total of 50 cases could be detected with an approximate cost of USD$ 176,000 per case detected

Análisis de costos de la tamización neonatal universal mediante espectrometría de masas en tándem para errores innatos del metabolismo en Colombia