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This chapter discusses the evaluation of risks and benefits associated with vaccination against coronavirus infections in cats. The current status of feline infectious peritonitis (FIP) varies among types of cat populations. It is the most feared disease today in breeding catteries, but is less common and of less concern in the general pet population. There is no effective treatment for FIP, and once classical disease occurs, mortality is nearly 100%. The only available commercial vaccine is less than 100% effective. Available laboratory tests detect feline coronavirus antibodies and therefore are not specific for FIP. Till now, there was no test to detect FIP antigen, virus, or to identify virus carrier cats. The reliability of new antigen detection tests is still being evaluated. A cattery with enzootic FIP is difficult to manage. The great variability in incubation period of FIP (weeks, months, or even years) presents a serious challenge to prevention and control. The causative agent of FIP, feline infectious peritonitis virus (FIPV), is a pleomorphic, enveloped virus classified as a coronavirus.

Evaluation of Risks and Benefits Associated with Vaccination against Coronavirus Infections in Cats