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There is a continuing need for improved drugs for treatment and prevention of malaria. Drugs with causal prophylactic activity are especially useful for prevention of malaria in individuals with a limited duration of exposure in a malaria-endemic area. In this paper I compare the requirements for causal prophylaxis of relapsing and non-relapsing malarias and review some of the challenges to the development of new prophylactic antimalarial drugs.

Challenges in the development of antimalarial drugs with causal prophylactic activity