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• Sildenafil could have additional and prolonged beneficial effects on endothelial function in diabetic patients if taken on a daily basis Desouza et al, Diabetes Care 2002 Delphine Behr-Roussel, Diane Gorny, Katell Mevel, Stéphanie Caisey Jacques Bernabé, Gillian Burgess, Chris Wayman, Laurent Alexandre, François Giuliano 1 PELVIPHARM Laboratories, Gif-sur-Yvette, France 2 PFIZER Global Research and Development, Sandwich, UK 3 Medical University of Paris South, Research Group in Urology, Le Kremlin-Bicêtre, France* * giuliano@cyber-sante.org

1611: Chronic Sildenafil Enhances Erectile Responses and Endothelium-Dependent Corporal Relaxations of Normal Rats: Lack of Tachyphylaxis