English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effects of proadrenomedullin N-terminal 20 peptide (PAMP) on changes in renal function and norepinephrine (NE) overflow induced by renal nerve stimulation (RNS) were examined in anesthetized dogs. The intrarenal arterial infusion of PAMP (10, 50, 100 ng/kg/min) did not influence basal levels of systemic and renal hemodynamics, or urine formation. RNS at a low frequency (0.5-2.0 Hz) caused significant decreases in urine flow and urinary excretion of sodium, and increases in NE secretion rate (NESR), without affecting renal hemodynamics. RNS at a high frequency (2.5-5.0 Hz), which diminishes renal hemodynamics, elicited more potent decreases in urine formation and increases in NESR. The low frequency RNS-induced reductions in urine formation and increases in NESR were almost completely abolished by the intrarenal arterial infusion of PAMP at 50 ng/kg/min, a dose that produced no alterations on basal renal hemodynamics and excretory responses. In contrast, high frequency RNS-induced renal vasoconstriction and reductions in urine formation, and increases in NESR were not affected by infusion of the peptide. We next examined the effect of PAMP on exogenously applied NE-induced renal actions, to determine if PAMP functions suppressively at postjunctional sites. The intrarenal arterial infusion of NE (100-150 ng/kg/min) produced a significant renal vasoconstriction and a reduction in urine formation, responses not affected by the administration of PAMP (50 ng/kg/min). From these findings, we suggest that PAMP functions as an inhibitory modulator of renal noradrenergic neurotransmission, via prejunctional mechanisms, and plays an important role in regulating renal functions.

japanese journal of pharmacology/japanese journal of pharmacology

Effects of proadrenomedullin N-terminal 20 peptide on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs