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Rat arterial smooth muscle cells (SMC) are diverse in nature. In addition to SMC cultures which grow to the typical 'hill and valley' morphology at confluence, there are other SMC which show spindle shape, or thin and long fusiform swirling pattern, or which have a cobblestone appearance at confluence. The growth of these cell types is variably dependent on serum growth factors, and they display different cytoskeletal proteins. We wish to study the secretion of proteolytic enzymes and enzyme inhibitors from these SMC which may be important for their biological activities.

Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes