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Time for primary review 28 days. In his timely article [1], Dr. P.K. Singal reviews the relationship between oxidative stress, antioxidants and cardiac diseases. This field is the most extensively investigated area of cardiovascular research with consequential practical therapeutic ramifications. Unfortunately, the author’s presentation of the clinical effectiveness of various antioxidants in the prevention or restriction of the molecular, cellular and systems effects of oxidative stress is limited. An essential omission is the absence of any reference to the involvement and the well-studied clinical applications of coenzyme Q10 in various forms of cardiovascular diseases — a subject of great interest for the readers of this publication.Coenzyme Q10 (CoQ10, ubiquinone) is a naturally occuring, fat-soluble nutrient (a quinone), with characteristics that are common to vitamins and, like vitamins, is essential to the optimal functioning of an organism. CoQ10 is a potent and versatile antioxidant that is present in humans and in some animals. In addition to its antioxidant function, CoQ10 plays an indispensable role in intracellular energy production. Being a vital electron and proton carrier, CoQ10 supports adenosine triphosphate synthesis in the mitochondrial inner membrane and stabilizes cell membranes, thus preserving cellular integrity and function. Most CoQ10 clinical research is focused on the large, heterogeneous …

Cardiovascular diseases, oxidative stress and antioxidants: the decisive role of coenzyme Q10