English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

See article by Bayes-Genis et al. [10] (pages 404–410) in this issue. Currently, a paradigm shift from the widely accepted dogma of the heart being incapable of self-repair is occurring. This is mostly owing to recent revolutionary observations that host-derived stem cells, presumably mesenchymal stem cells derived from the bone marrow, can be recruited to, encraft within the myocardium and may participate in the regeneration of heart function [1–3]. The apparent plasticity of adult stem cells has prompted the possibility that bone marrow-derived mesenchymal cells could be isolated from patients, sub-cultivated in vitro and reintroduced after occurrence of heart disease. Bone marrow cells and cardiomyocytes are both arising from the early mesoderm. However, the cardiomyocyte progenitors are developed from the lateral plate mesoderm under the inducing influence of differentiation factors secreted by the adjacent endoderm, whereas the bone marrow is derived from the somitic dorsal mesoderm. Despite these differences in origin, several studies performed on rodents [3–6], pigs [7] as well as on humans [8,9] have conclusively demonstrated that mesenchymal stem cells own the potency to differentiate to a cardiomyocyte phenotype in the adult heart. With the study of Bayes-Genis et al. in this issue [10], further evidence is provided that stem cells, presumably mesenchymal stem cells derived from the … * Corresponding author. Tel.: +49-221-478-6976; fax: +49-221-344-527

Cardiac differentiation of mesenchymal stem cells in sex mis-matched transplanted hearts: self-repair or just a visit?