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Tumor necrosis factor alpha (TNFalpha) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNFalpha-preconditioning is mediated by 'established' preconditioning signaling or via novel signaling cascades. Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined.

Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFα gene