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See article by Verma et al. [4] (pages 146–151) in this issue. Since the experiments of Furchgott and Zawadzki [1] at the end-seventies, there is an increased number of research projects on the endothelium and the endothelial function in vascular regulation. The experimental data produced then has reached tremendous quantities. Now we know that the endothelium plays a role as an autocrine and paracrine producer of vascular active substances [2], either with a constricting or a dilating effect of blood vessels, either directly or indirectly acting. Irregularities in this balance could be responsible for increased tone in vascular smooth muscle cells, altered reactivity and vasomotion, and over a longer period to changes in structure and geometry and to enhanced platelet aggregation.One of the most potent vasoactive agents found to be produced in the vascular endothelium, are the so-called endothelins (ET). This group of vasoactive polypeptides contains different subgroups with subsequent different receptor subtypes. Two receptor subtypes have been cloned in blood vessels, namely, the ETA receptor, which preferentially binds … * Corresponding author. Tel.: +31-20-566-3325; fax: +31-20-697-9441 n.hoogerwerf{at}amc.uva.nl

A role for endothelin receptor blockade in improving the endothelial function of coronary artery grafts?