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Although it is known that endothelin (ET-1) is elevated in heart failure (HF), it remains unclear if chronic ET(A/B) receptor antagonism affects the progression of HF, particularly by affecting coronary vasoactivity and left ventricular (LV) diastolic function.

cardiovascular research

Chronic therapy with an ETA/B receptor antagonist in conscious dogs during progression of congestive heart failure Intracellular Ca2+ regulation and nitric oxide mediated coronary relaxation