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The aim of this study was to investigate whether trimetazidine (TMZ; 10(-6)M), which has been shown to inhibit fatty acid oxidation, reduces the ionic imbalance induced by ischaemia and reperfusion, especially through an attenuation in intracellular changes in H(+) and Na(+).

Changes in intracellular sodium and pH during ischaemia–reperfusion are attenuated by trimetazidine Comparison between low- and zero-flow ischaemia