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Although the technique of three-dimensional mapping obviously does not provide direct evidence as to whether ET-1-induced ventricular arrhythmias are purely due to ischemia or to a combination of direct electrophysiologic effects and ischemia, we still believe that a number of aspects argue against the hypothesis that ET-1 related arrhythmogenesis is exclusively based on ischemia:1. The fact that conduction and refractory properties remained entirely unaffected by ET-1.2. The difference in the mechanism responsible for the maintenance of …

cardiovascular research

Re: 'Ventricular arrhythmias induced by endothelin-1 or by acute ischemia: a comparative analysis using three-dimensional mapping' (Cardiovasc Res 2000;45:310–320)