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During the past decade following the publication of the World Health Organization (WHO) classification of renal tumors in 2004,1 urologists and pathologists have encountered a surge of new entities of renal neoplasms. Scrutiny of subtle histologic features, detailed marker analyses, as well as advances in novel molecular and cytogenetic techniques all facilitate to characterize these entities that were either inadequately defined or categorized as other diseases in the past. The International Society of Urological Pathology (ISUP) is the international professional organization dedicated to the subspecialty of urological pathology. In 2011, the Society undertook to review all aspects of the pathology of adult renal malignancy through an international consensus conference held in 2012 in Vancouver, Canada.2 The classification working group of the ISUP consensus conference on renal neoplasia was entrusted with the responsibility of reviewing available literature and making

The International Society of Urological Pathology/Vancouver Classification of Renal Neoplasia: New entities of adult renal cell carcinoma