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In this issue of the Journal, we are pleased to introduce the winners of the 2015 Taiwanese Journal of Obstetrics and Gynecology (TJOG) Outstanding Research Paper Award. The awards were selected from among research papers published in the 2015 print issues of the TJOG. The 2015 TJOG Outstanding Research Paper Golden Award winner was Dr. Wang, for his research paper entitled “The role of nitric oxide in the outgrowth of trophoblast cells on human umbilical vein endothelial cells” [1]. The 2015 TJOG Outstanding Research Paper Silver Award winner was Dr. Chen, for her research paper entitled “Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome” [2]. Both winners received their honors at the Annual Meeting of the Taiwan Association of Obstetrics and Gynecology on March 5, 2016 and March 6, 2016, held in Taipei, Taiwan. The golden award-winning research article was published in the June 2015 issue. This article was cooperated by two institutes to finish this work, including two directors of the reproductive medicine in both institutes (Dr. Kuan Hao Tsui and Dr. Hsin-Yang Li). The results showed that N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME), a competitive inhibitor of nitric oxide synthase (NOS), could diminish spheroid expansion on human umbilical vein endothelial cell (HUVEC) monolayers in a concentrationdependent manner (p< 0.05), suggesting the importance of nitric oxide (NO) availability. However, a higher dose (1mM) of sodium nitroprusside (SNP), an NO donor, significantly suppressed spheroid expansion, suggesting that the overproduction of NO might impede the normal interaction between trophoblast and HUVEC [1]. The study further showed that trophoblast spreading on HUVEC-free culture surface was not affected by NOS inhibitor or NO, confirming that NO is needed on the interaction between trophoblast and HUVEC. Taken together, the authors concluded that the interaction of trophoblasts and HUVEC is dependent on an adequate and approximate NO-containing environment, and either over or under NO environment will deteriorate the interaction between trophoblast and HUVEC [1]. The silver award-winning research article by Dr. Mei-Jou Chen was published in the December 2015 issue [2]. The authors found that polycystic ovary syndrome (PCOS) women with obesity had significantly higher ferritin, and lower anti-Müllerian hormone (AMH) levels than PCOS women without obesity. In the earlier August 2015 issue, Drs. Ming-I Hsu and Chun-Sen Hsu published a similar paper, but this article focused on the relationship between serum ferritin levels and PCO-related complication [3].

Outstanding research paper awards of the 2015 Taiwanese Journal of Obstetrics and Gynecology