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AbstractA 27-year-old woman had acute panuveitis, associated with bilateral knee pain with morning stiffness, erythematous papules on the bilateral anterior legs, vertigo, and hearing impairment 4 days after administration of the third dose of quadrivalent human papillomavirus vaccine (HPV4). The only abnormal laboratory finding was an elevated erythrocyte sedimentation rate. Skin biopsy of the local erythematous papules disclosed septal panniculitis with lymphocytic vasculitis. Complete remission was achieved with oral and topical steroids for 4 months. There was no recurrence in the following 2 years. Ophthalmologists and primary-care physicians should be aware of this possible adverse reaction to HPV4

Panuveitis following administration of quadrivalent human papillomavirus vaccine