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Cell size of bacteria M is related to 3 temporal parameters: chromosome replication time C , period from replication-termination to subsequent division D , and doubling time τ . Steady-state, bacillary cells grow exponentially by extending length L only, but their constant width W is larger at shorter τ 's or longer C 's, in proportion to the number of chromosome replication positions n (= C / τ ), at least in Escherichia coli and Salmonella typhimurium . Extending C by hymine limitation of fast-growing hyA mutants result in continuous increase of M , associated with rising W , up to a limit before branching. A set of such puzzling observations is qualitatively consistent with the view that the actual cell mass (or volume) at the time of replication-initiation Mi (or Vi ), usually relatively constant in growth at varying τ 's, rises with time under thymine limitation of fast-growing, thymine-requiring E. coli strains. The hypothesis will be tested that presumes existence of a minimal distance l  min between successive moving replisomes, translated into the time needed for a replisome to reach l  min before a new replication-initiation a oriC is allowed, termed Eclipse E . Preliminary analysis of currently available data is inconsistent with a constan E under all conditions, hence other explanations and ways to test them are proposed in an attempt to elucidate these and other results. The complex hypothesis takes into account much of what is currently known about Bacterial Physiology: the relationships between cell dimensions, growth and cycle parameters, particularly nucleoid structure, replication and position, and the mode of peptidoglycan biosynthesis. Further experiments are mentioned that are necessary to test the discussed ideas and hypotheses.

Does the eclipse limit bacterial nucleoid complexity and cell width?