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Objective: 25-hydroxyvitamin D (25OHD) deficiency has been associated withsleep disorders in adults. Only three cross-sectional studies were performed inchildren and showed an association between 25OHD deficiency and bothobstructive sleep apnea syndrome and primary snoring. No longitudinal study hasbeen performed in children from the general population. We analyzed theassociation between cord-blood vitamin D level at birth and night-sleepduration trajectories for children between 2 and 5-6 years old in anon-clinical cohort.Method: We included 264 children from the French EDENmother-child birth-cohort with both cord-blood 25OHD level determined byradio-immunoassay at birth, and night-sleep trajectories for children between 2and 5-6 years old obtained by the group-based trajectory modeling method.Associations between 25OHD and sleep trajectories were assessed by multinomiallogistic regression adjusted for maternal and child characteristics.Results:The trajectories short sleep (<10h30/night), medium-low sleep(10h30-11h00/night), medium-high sleep ($\approx$11h30/night), long sleep($\ge$11h30/night) and changing sleep (decreased from $\ge$11h30 to10h30-11h00/night) represented 5%, 46%, 37%, 4% and 8% of the children,respectively. The mean 25OHD level was 19 ng/ml (SD=11, range 3 to 63). It was12 (SD=7), 20 (SD=11), 19 (SD=10), 14 (SD=7) and 16 (SD=8) ng/ml for childrenwith short, medium-low, medium-high, long and changing sleep trajectories,respectively. On adjusted analysis, for each 1-ng/ml decrease in 25OHD level,the odds of belonging to the short sleep versus medium-high sleep trajectorywas increased (odds ratio =1.12, 95% confidence interval [1.01-1.25]). We foundno other significant association between 25OHD level and othertrajectories.Conclusion: Low 25OHD level at birth may be associated withincreased probability of being a persistent short sleeper in preschool years.These results need confirmation.

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort