English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Osteoarthritis (OA) is the most common degenerative joint disease and a growing health problem affecting more than half of the population over the age of 65. It is characterized by inflammation in the cartilage and synovium, resulting in the loss of joint structure and progressive damage to the cartilage. Many pro-inflammatory mediators are elevated in OA, including reactive oxygen species (ROS) such as nitric oxide (NO) and hydrogen peroxide (H 2 O 2 ). Damaged articular cartilage remains a challenge to treat due to the limited self-healing capacity of the tissue and unsuccessful biological interventions. This highlights the need for better therapeutic strategies to heal damaged articular cartilage. Ozone (O 3 ) therapy has been shown to have positive results in the treatment of OA; however the use of O 3 herapy as a therapeutic agent is controversial. There is a perception that O 3 is always toxic, whereas evidence indicates that when it is applied following a specified method, O 3 can be effective in the treatment of degenerative diseases. The mechanism of action of O 3 herapy in OA is not fully understood and this review summarizes the use of O 3 herapy in the treatment of damaged articular cartilage in OA.

Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis