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Many athletes adopt nutritional manipulations to improve their performance. Among the substances generally consumed, carnitine (L-trimethyl-3-hydroxy-ammoniobutanoate) has been used by athletes as an ergogenic aid because of its role in the transport of long-chain fatty acids across mitochondrial membranes.AimThis study was performed with purpose to determine the effect of chronic carnitine supplementation on aerobic performance and fat-carbohydrate metabolism enzymes and cardiovascular factors.MethodIn a randomized, placebo-controlled, double-blind crossover design, Thirty healthy untrained males cycled for 20min at 70% maximal O2 uptake (VO2max) in two separate stages (baseline and while ingested oral L-carnitine (Int) or lactose (Con), 3g daily for 3 Week). Blood samples were drawn for the purpose of calculation plasma glucose and Lactate concentration, lactate dehydrogenase activity (LDH), heart rate and VO2max. A two-way repeated measure ANOVA was used to determine significant differences between the two groups. Statically significant was accepted at (P<0.05).ResultThe finding of our study showed that L-carnitine supplementation had no influence on plasma glucose and lactate concentration. Also rest and submaximal heart rate, VO2max and LDH activity was equal in pre and posttest (P<0.05). All variables unaffected in the placebo trial.DiscussionOur finding indicated that L-carnitine L-tartarate ingestion, 3g for 3 week could not affect mentioned variables and aerobic capacity. Additional investigation is required to directly identify these supplementations on the substrate utilization and fat-carbohydrate metabolism and exercise performance

The effect of chronic l- carnitine l-tartarate supplementation on glucose and lactate concentration and aerobic capacity