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Oral squamous cell carcinoma (OSCC) is a malignant neoplasia originated in the epithelium's keratocytes. Early biopsies reveal dysplastic mitotic keratocytes and sub-epithelial inflammatory infiltrate which progress towards a loss of basal membrane. Nevertheless, hematoxillin and eosin (HE this aspect improves when molecular markers such as Ki-67 and cyclin D1 are used. The aim of the present study was to correlate histological description of OSCC cases with Ki-676 and cyclin D1 expression. Material and methods Twelve patients with lesions suggestive of oral cancer were analyzed, patients with OSCC diagnosis were included in the study. Single biopsies were taken, observing histological and technical processing for paraffin cuts, coloration with HE C2 exhibited Ki-67 negative and cyclin D1 positive, and C3 showed Ki-67 positive and cyclin D1 negative. Conclusions Search for markers such as Ki-67 and cyclin D1 in pre-established OSCC diagnoses can influence histological results, contributing thus to more accurate diagnosis and treatment for the patients.

Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity