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We develop a general framework for the discussion of detailed balance andanalyse its microscopic background. We find that there should be two additionsto the well-known $T$- or $PT$-invariance of the microscopic laws of motion:  1. Equilibrium should not spontaneously break the relevant $T$- or$PT$-symmetry.  2. The macroscopic processes should be microscopically distinguishable toguarantee persistence of detailed balance in the model reduction from micro- tomacrokinetics.  We briefly discuss examples of the violation of these rules and thecorresponding violation of detailed balance.

Detailed balance in micro- and macrokinetics and micro-distinguishability of macro-processes