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Drug-induced liver injury (DILI) is one of the most challenging disorders faced by the gastroenterologist. The estimated annual incidence rate of DILI is 13.9-24 per 100,000 inhabitants. It is still a diagnosis of exclusion based primarily on a detailed history and the judicious use of blood tests, hepatobiliary imaging, and liver biopsy. Herbal and dietary supplements (HDSs) are currently consumed on a large scale in Mexico, due to the common misperception that they are innocuous because they are ‘‘natural’’. However, HDS hepatotoxicity has received increasing attention over the past few years, in part because HDSs have been recognized in the United States as being the second most common cause of DILI cases. The Adverse Event Reporting Program of the Food and Drug Administration is responsible for the increased awareness of safety concerns and encourages individuals and healthcare professionals to report adverse effects. We present herein the case of a 25-year-old woman diagnosed with acute herbalinduced hepatotoxicity secondary to the consumption, in the form of an infusion, of Cochlospermum vitifolium (C. vitifolium). Commonly known as ‘‘yellow rose,’’ ‘‘panicua’’, or ‘‘pongolote’’, it is used as an herbal remedy for the ‘‘treatment’’ of jaundice and metabolic syndrome. Wild C. vitifolium belongs to the Cochlospermaceae family and is a shrub with yellow flowers that grows up to

The dark story of the yellow rose: A case report of hepatoxicity associated with Cochlospermum vitifolium consumption as herbal remedy