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White adipose tissue is a highly active metabolic and endocrine tissue formed of adipocytes and the stromal vascular fraction (preadipocytes, mesenchymal progenitor cells, endothelial cells, pericytes, macrophages and fibroblasts). The crosstalk between these cell populations provides high dynamicity and plasticity in response to environmental changes and energy status. While insulin stimulates triacylglyceride (TAG) synthesis through sterol regulatory element-binding transcription factor 1c (SREBP1c)-induced lipogenesis after meals, other factors like glucagon, cortisol, growth hormone and thyroid hormones stimulate the hydrolysis of stored TAGs into fatty acids and glycerol (lipolysis). Lipid anabolism and consequent tissue expansion require dynamicity and plasticity of the vasculature, avoiding formation of hypoxic regions, which are usually associated with inflammation and fibrosis. Differentiation of preadipocytes into mature adipocytes

Epicardial adipose tissue (dys)function: A new player in heart disease?