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Myocardial infarction (MI) remains one of the leading causes of morbidity and mortality worldwide. Following MI, the injured myocardium is replaced by fibrotic tissue, resulting in reduced contractility and ventricular remodeling that can lead to the development of heart failure. The classical view of the human heart as a postmitotic organ incapable of self-regeneration has been overturned, largely by a study by Quaini et al. in the New England Journal of Medicine in 2002 that identified cardiac cells with the Y chromosome in hearts from female donors transplanted into male recipients. This landmark study demonstrated cardiac regeneration in adults by showing that stem cells can migrate from the host to the transplanted heart, where they develop into cardiac cells. Various studies over the last two decades have produced promising results concerning the ability of stem cells to promote cardiac regeneration, in both animal models and clinical trials. Mesenchymal stem cells (MSCs) are non-hematopoietic adult stem cells produced in bone marrow that are capable

Terapêutica combinada de células estaminais mesenquimatosas e exercício físico no enfarte agudo do miocárdio: uma simbiose perfeita?