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We would like to thank Mustafa Gülgün for his interest in our manuscript. We investigated calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio (LMR). We found a statistically significant difference in terms of LMR in patients compared with healthy controls and also found an inverse relationship between severity of calcific aortic stenosis and LMR. Mustafa Gülgün pointed out that the lymphocyte cell count is affected by various clinical factors such as gender, age, race, time of sampling, physical and psychological stress, pregnancy, drugs, infections, smoking, presence of anti-lymphocyte autoantibodies and procedures such as splenectomy. As we stated in our paper, we excluded patients that had active or chronic infection, systemic inflammatory or allergic disease, and renal, hepatic or hematologic disease. Besides, there were there no

revista portuguesa de cardiologia

Reply to the Letter to the Editor “Methodology, as well as physiological and pathological conditions, can affect analysis of the lymphocyte-to-monocyte ratio”