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Among percutaneous techniques, renal sympathetic denervation has probably generated the greatest expectations in recent years. The possibility of non-pharmacological treatment of hypertension has aroused interest not only in the medical and scientific community but also in the nonspecialist media and the general population. Pilot studies reported results that many considered too good to be true, but despite this skepticism, they were also too good to be ignored, given the large scale of this health problem. The technique is commercially available in many countries and has been applied primarily in patients with resistant hypertension. It is estimated that, two years after the publication of the Symplicity HTN-2 study, over 5000 patients have been treated. The initial experience of centers using the technique has been similar to that reported in the pilot studies, although with a higher but still acceptable rate of non-responders. Registries have been established whose preliminary results have gone some way to validating the method. Another important development has been the widening of selection criteria to include less severe forms of hypertension, which is contrary to the recommendations of medical societies. Nevertheless, even here the results have been favorable in terms of safety and hemodynamic benefits. Other benefits have also been reported, including improvements in glucose metabolism

Desnervação simpática renal – fenómeno ou númeno?