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Availability of powerful intravenous hypnotics and opioids with specific pharmacokinetic profiles, including rapid onset and short duration of action1 has allowed the development and popularization of total intravenous anesthesia (TIVA). Due to its safety, rapid titrability, quick recovery with better operating room efficiency, and a low incidence of nausea and vomiting,2,3 TIVA has become a valid alternative to inhaled general anesthesia. There are several modes of TIVA administration that range from the simple intermittent injection of small boluses of hypnotics with or without opioids to the infusion of anesthetics using complex computerized infusion pumps. Target-controlled infusion (TCI) TIVA consists of the administration of intravenous anesthetics according to their pharmacokinetic profiles in order to maintain desired concentration of the drugs in the central compartment (effectsite concentration). Computerized infusion devices equipped with software that continuously controls the infusion rates of the drugs are used for this purpose. The software includes pharmacokinetic models derived from studies involving volunteers with diverse demographic characteristics. The models are mathematical algorithms used to predict the plasma concentration of a drug after the administration of a bolus or after an infusion of varying duration. The TCI system uses the pharmacokinetic models to calculates the dose regimen for each drug, which usually consists of a bolus dose delivered to fill the central compartment (plasma), a constant infusion

La caracterización de la profundidad de la anestesia durante las infusiones controladas a objetivo: no es un trabajo fácil