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Praise to the authors for having rigorously selected eligible studies prior to embarking on their analysis. The message is clear. Unfortunately, the calculations are in error as alleles were muddled in one of the four inves-tigations on which the random effects model was based: Lemonde et 2al. examined the transcribed DNA strand, whereas the remaining studies refer to the anti-parallel strand. When this is overlooked, G and C alleles are ex-changed and the G allele becomes risk-enhancing rather than protective. Even if the data in question are dropped on the grounds of heterogeneity, I have counted four ad-ditional studies of which at least one

Negligible impact of a HTR1A gene promoter variant on suicidal behavior