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This study was to investigate the quinolone resistance to gram negative bacteria isolated in the First Bethune Hospital during the past 8 years. Disk diffusion test was used to study the antimicrobial resistance. The data were analyzed by WHONET 5 software according to Clinical and Laboratory Standards Institute(CLSI). The rates of extended spectrum beta-lactamases(ESBLs) in Escherichia coli and Klebsiella.spp were 43.6%∼60.1% and 51.0%∼65.1% during the past 8 years, respectively. In recent 8 years, the quinolone resistance to gram negative bacteria had increased. In particular, Escherichia coli resistant to quinolones was more obvious. Monitoring of the quinolone resistance to gram negative bacteria should be strengthened. The change of the antimicrobial resistance should be investigated in order to guide direct rational drug usage in the clinic and prevent bacterial strain of drug resistancefrom being transmitted

Changes of the Quinolone Resistance to Gram Negative Bacteria Isolated During the Past 8 Years in the First Bethune Hospital