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The reaction in the human stomach when neutralizing acid with an antacid tablet is simu- lated and the evolution over time of the concentration of all chemical species present in the reaction medium is obtained. The values of the kinetic parameters of the chemical reaction can be determined by integrating the equation of the reaction rate. This is a classical opti- mization problem that can be approached with metaheuristic methods. The use of a parallel, parameterized scheme for metaheuristics facilitates the development of metaheuristics and their application. The unified scheme can also be used to implement hyperheuristics on top of pa- rameterized metaheuristics, so selecting appropriate values for the metaheuristic parameters, and consequently the metaheuristic itself. The hyperheuristic approach provides satisfactory values for the metaheuristic parameters and, consequently, satisfactory metaheuristics for the problem of determining the kinetic constants

Using Hyperheuristics to Improve the Determination of the Kinetic Constants of a Chemical Reaction in Heterogeneous Phase