English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

We describe a 3D percolation-type approach to modeling of the processes ofaging and certain other properties of tissues analyzed as systems consisting ofinteracting cells. Lattice sites are designated as regular (healthy) cells,senescent cells, or vacancies left by dead (apoptotic) cells. The system isthen studied dynamically with the ongoing processes including regular celldividing to fill vacant sites, healthy cells becoming senescent or dying, andsenescent cells dying. Statistical-mechanics description can provide patternsof time dependence and snapshots of morphological system properties. Thedeveloped theoretical modeling approach is found not only to corroborate recentexperimental findings that inhibition of senescence can lead to extendedlifespan, but also to confirm that, unlike 2D, in 3D senescent cells cancontribute to tissue's connectivity/mechanical stability. The latter effectoccurs by senescent cells forming the second infinite cluster in the regimewhen the regular (healthy) cell's infinite cluster still exits.

Lattice Percolation Approach to 3D Modeling of Tissue Aging