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We consider the dynamics of cargo driven by a collection of interactingmolecular motors in the context of an asymmetric simple exclusion processes(ASEP). The model is formulated to account for i) excluded volume interactions,ii) the observed asymmetry of the stochastic movement of individual motors andiii) interactions between motors and cargo. Items (i) and (ii) form the basisof ASEP models and have already been considered in the literature to study thebehavior of motor density profile [Parmeggiani 03]. Item (iii) is new. It isintroduced here as an attempt to describe explicitly the dependence of cargomovement on the dynamics of motors. The steady-state solutions of the modelindicate that the system undergoes a phase transition of condensation type asthe motor density varies. We study the consequences of this transition to theproperties of cargo velocity.

The dynamics of cargo driven by molecular motors in the context of asymmetric simple exclusion processes