Open AccessRole of Zc3h12a in enhanced IL-6 production by newborn mononuclear cells in response to lipopolysaccharide
Author(s) -
Xiafang Chen,
Jing Wu,
Yidan Zhang,
Chenxing Zhang,
Xuting Chen,
Jianhua Sun,
TongXin Chen
Publication year - 2017
Publication title -
pediatrics and neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 36
eISSN - 2212-1692
pISSN - 1875-9572
DOI - 10.1016/j.pedneo.2017.09.006
Subject(s) - medicine , peripheral blood mononuclear cell , lipopolysaccharide , tlr4 , secretion , pathogenesis , interleukin , immunology , flow cytometry , venous blood , andrology , endocrinology , in vitro , inflammation , cytokine , biology , biochemistry
The uncontrolled inflammatory response following infection is closely related to the morbidity and mortality of neonates. Interleukin 6 (IL-6) plays an important role in the pathogenesis and prognosis of this process. To better elucidate the secretion of IL-6 following infection in neonates, we investigated the IL-6 level and mechanism of IL-6/TLR4 signaling pathways.
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