Open AccessEffect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities
Author(s) -
Junli Jiang,
Chunchun Tang,
Juanjuan Ren,
Chao Zhang,
Liang Dong,
Zhaoqiong Zhu
Publication year - 2017
Publication title -
pediatrics and neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 36
eISSN - 2212-1692
pISSN - 1875-9572
DOI - 10.1016/j.pedneo.2017.08.007
Subject(s) - hippocampal formation , medicine , sevoflurane , dentate gyrus , hippocampus , anesthesia , magnetic resonance imaging , endocrinology , apolipoprotein e , radiology , disease
Sevoflurane anesthesia is widely used in pediatric patients. In this study, we investigated whether early multiple exposures to sevoflurane induced cognitive dysfunction by altering the hippocampal expression of ApoE later in development.
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