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The pearl in this “neuropathic” pain patient, studied by Jorum et al, is activation of three nociceptors in hyperalgesic skin by reflex sympathetic maneuvers and by ID norepinephrine. What does it mean?

Letter to the Editor of Pain on Jørum et al: Catecholamine-induced excitation of nociceptors in sympathetically maintained pain; Pain 2007;127:296–301