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The suppression of D mesons in non-central heavy-ion collisions isinvestigated. The anisotropy in collisions at finite impact parameter leads toan ordering of all-angle, in- and out-of-plane nuclear modification factors dueto the different in-medium path lengths. Within our MC@sHQ+EPOS model ofheavy-quark propagation in the QGP we demonstrate that fluctuating initialconditions lead to an effective reduction of the energy loss of heavy quarks,which is seen in a larger nuclear modification factor at intermediate and hightransverse momenta. The elliptic flow at small transverse momenta is reduced.

D mesons in non-central heavy-ion collisions: fluctuating vs. averaged initial conditions