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Electrospun nanofibrous membranes of natural polymers, such as gelatin, arefundamental in the design of regenerative devices. Crosslinking of electrospunfibres from gelatin is required to prevent dissolution in water, to retain theoriginal nanofibre morphology after immersion in water, and to improve thethermal and mechanical properties, although this is still challenging toaccomplish in a controlled fashion. In this study, we have investigated thescalable manufacture and structural stability in aqueous environment of aUV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES)of aqueous solutions containing vinylbenzylated gelatin andpoly(epsilon-caprolactone) dimethacrylate (PCL-DMA). Vinylbenzylated gelatinwas obtained via chemical functionalisation with photopolymerisable4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase inelectrospun fibres were integrated in a covalent UV-cured co-network at themolecular scale, rather than being simply physically mixed. UV-curednanofibrous membranes did not dissolve in water and showed enhanced thermal andmechanical properties, with respect to as-spun samples, indicating theeffectiveness of the photo-crosslinking reaction. In addition, UV-curedgelatin/PCL membranes displayed increased structural stability in water withrespect to PCL-free samples and were highly tolerated by G292 osteosarcomacells. These results therefore support the use of PCL DMA as hydrophobic,biodegradable crosslinker and provide new insight on the scalable design ofwater insoluble, mechanical competent gelatin membranes for healthcareapplications.

materials science and engineering c

A UV-cured nanofibrous membrane of vinylbenzylated  gelatin-poly({\epsilon}-caprolactone) dimethacrylate co-network by scalable  free surface electrospinning