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Purpose: To develop an accelerated Cartesian MRF implementation using amulti-shot EPI sequence for rapid simultaneous quantification of T1 and T2parameters. Methods: The proposed Cartesian MRF method involved the acquisitionof highly subsampled MR images using a 16-shot EPI readout. A linearly varyingflip angle train was used for rapid, simultaneous T1 and T2 quantification. Theaccuracy of parametric map estimations were improved by using an iterativeprojection algorithm. The results were compared to a conventional spiral MRFimplementation. The acquisition time per slice was 8s and this method wasvalidated on a phantom and a healthy volunteer brain in vivo. Results: Joint T1and T2 estimations using the 16-shot EPI readout are in good agreement with thespiral implementation using the same acquisition parameters (deviation lessthan 3% for T1 and less than 4% for T2) for the healthy volunteer brain. The T1and T2 values also agree with the conventional values previously reported inthe literature. The visual quality of the multi-parametric maps generated bythe multi-shot EPI-MRF and spiral-MRF implementations were comparable.Conclusion: The multi-shot EPI-MRF method generated accurate quantitativemulti-parametric maps similar to conventional Spiral - MRF. This multi-shotapproach achieved provides an alternative for performing MRF using anaccelerated Cartesian readout, thereby increasing the potential usability ofMRF.

Multi-shot Echo Planar Imaging for accelerated Cartesian MR Fingerprinting: an alternative to conventional spiral MR Fingerprinting