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Mixed fungal infection and acquired echinocandin resistance of Candida spp. remain infrequent. In this study we have reported the case of a patient hospitalized for tuberculosis who experienced multiple infections due to three common Candida species ( C. albicans, C. glabrata, C. tropicalis ). Furthermore, consecutive isolates from blood cultures and heart valve were found resistant to azoles ( C. tropicalis ) and to echinocandin with either novel ( C. tropicalis ) or previously described ( C. albicans ) missense mutations in the Fks gene.

Recurrent episodes of Candidemia due to Candida glabrata, Candida tropicalis and Candida albicans with acquired echinocandin resistance