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The design of antibacterial-releasing coatings or wrapping materials withcontrolled drug release capability is a promising strategy to minimise risks ofinfection and medical device failure in vivo. Collagen fibres have beenemployed as medical device building block, although they still fail to displaycontrolled release capability, competitive wet-state mechanical properties, andretained triple helix organisation. We investigated this challenge by pursuinga multiscale design approach integrating drug encapsulation, in-situ covalentcrosslinking and fibre spinning. By selecting ciprofloxacin (Cip) as a typicalantibacterial drug, wet spinning was selected as a triple helix-friendly routetowards Cip-encapsulated collagen fibres; whilst in situ crosslinking offibre-forming triple helices with 1,3 phenylenediacetic acid (Ph) washypothesised to yield Ph-Cip {\pi}-{\pi} stacking aromatic interactions andenable controlled drug release. Higher tensile modulus and strength weremeasured in Ph crosslinked fibres compared to state-of-the-art carbodiimidecrosslinked controls. Cip-encapsulated Ph-crosslinked fibres revealed decreasedelongation at break and significantly-enhanced drug retention in vitro withrespect to Cip-free variants and carbodiimide-crosslinked controls,respectively. This multiscale manufacturing strategy provides new insightaiming at wet spun collagen triple helices with nanoscale-regulated tensileproperties and drug release capability.

In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability