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Chitosan (CT) is an antibacterial polysaccharide that has been investigatedfor drug carriers, haemostats and wound dressings. For these applications,customised CT devices can often be obtained with specific experimentalconditions, which can irreversibly alter native biopolymer properties andfunctions and lead to unreliable material behaviour. In order to investigatethe structure-function relationships in CT covalent networks, monosodium5-sulfoisophthalate (PhS) was selected as heparin-mimicking, growthfactor-binding crosslinking segment, whilst 1,4-phenylenediacetic acid (4Ph)and poly(ethylene glycol) bis(carboxymethyl) ether (PEG) were employed assulfonic acid-free diacids of low and high crosslinker length respectively.Hydrogels based on short crosslinkers (PhS and 4Ph) displayed increasedcrosslink density, decreased swelling ratio as well as minimal hydrolytic andlysozymic degradation, whilst addition of lysozymes to PEG based networksresulted in 70 wt.-% mass loss. PhS-crosslinked CT hydrogels displayed thehighest loss (40 +/- 6 CFU%) of antibacterial activity upon incubation withPorphyromonas gingivalis, whilst respective extracts were tolerated by L929mouse fibroblasts.

Hydrolytic and lysozymic degradability of chitosan systems with heparin-mimicking pendant groups