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Leptin and adiponectin come from adipose tissue, which can reflect patients' inflammation and status of lipid metabolism. Our study is aim to evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on nutrition and lipid metabolic disturbance in chronic glomeruloneph-ritis with HBV patients. 17 patients were randomized to either low DPI with keto acid-supplemented (sLP) or low DPI (LP) group for 12 weeks. Low-protein diet (LPD) wasindividualized with protein intake of 0.6–0.8g/kg/day and keto acids were supplied in 0.1g/kg/day. Nutritional index other clinical index were measured to evaluate the effect and safey respectively. Serum levels of adiponectin, leptin were determined by ELISA assay.The urine protein excretion level was significantly decreased after 12 weeks in the sLP group compared to the basal value and the LP group (baseline:4.52±1.74,4 weeks:3.19±1.52g,8 weeks: 2.19±1.1g,12 weeks:1.64±0.77g, P<0.05).No difference was observed in serume creatinine, eGFR. Nutritional index was significantly improved at week 12 in the sLP group. 4 week later, Serum leptin of sLP decreased signficangly compared with baseline.[baseline: 4.99 (1.66, 11.44)ng/ml, 4 weeks: 2.29 (1.22,10.2)ng/ml;8 weeks: 1.8(1.18,5.07)ng/ml; 12 weeks: 1.38(0.88,2.55)ng/ml, P<0.05]. The level of serum adiponectin in sLP raised after 8 week compared with the baseline and LP (baselin: 21.60±4.78pg/ml, 4 weeks: 22.30±4.98pg/ml, 8 weeks: 24.44±4.43pg/ml, 12 weeks: 25.11±4.25pg/ml, P<0.05).In conclusion: Short-term restriction of DPI 0.6–0.8g of protein/kg IBW/day is safe, when combined with keto acids, is associated with decreased of urinary protein and improvement of lipid metabolis

Adiponectin,leptin: focus on low-protein diet supplemented with keto acids in chronic glomerulonephritis with hbv patients