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AND OBJECTIVES: We investigated combined therapeutic efficacy of human adipose-derived stem cells (h-ADSCs) application on injured cavernous nerve and low-energy shockwave therapy (SWT) on the corpus cavernosum in a rat model of post-prostatectomy erectile dysfunction. METHODS: Rats were randomly divided into five groups: Control, BCNI (bilateral cavernous nerve injury), ADSC (BCNI group with h-ADSCs on the cavernous nerve), SWT (BCNI group with lowenergy SWT on the corpus cavernosum), and ADSC/SWT (BCNI group with a combination of h-ADSCs and low-energy SWT). After four weeks, erectile function was assessed using intracavernosal pressure (ICP). The cavernous nerves and penile tissue were evaluated through immunostaining, western blotting and a cyclic guanosine monophosphate (cGMP) assay. RESULTS: ADSC/SWT significantly improved ICP compared to the other experimental group. ADSC had significantly increased ß-III tubulin expression of cavernous nerve, and SWT had markedly enhanced vascular endothelial growth factor (VEGF) expression in corpus cavernosum. The ADSC/SWT group had a significantly increased in alpha smooth muscle content (P <.05), neural nitric oxide synthase (nNOS) of the dorsal penile nerve (P <.05), endothelial nitric oxide synthase (eNOS) protein expression (P <.05), and cGMP level (P <.05) compared to ADSC or SWT alone group. In addition, ADSC/SWT reduces the apoptotic index in corpus cavernosum. CONCLUSIONS: In this study, h-ADSCs showed effect on recovery of injured cavernous nerve and low-energy SWT improved angiogenesis in the corpus cavernosum. The h-ADSCs combined with low energy SWT showed beneficial effect on the recovery of erectile function in a rat model of post-prostatectomy erectile dysfunction.

MP86-08 EFFECT OF COMBINATION THERAPY WITH NERVE GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR IN A RAT MODEL OF CAVERNOUS NERVE INJURY