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PACAP and receptors are expressed in micturition pathways. Studies show that PACAP has a role in detrusor smooth muscle contraction to facilitate adenosine triphosphate release from urothelium and PACAP antagonism decreases cyclophosphamide induced bladder hyperreflexia.

Bladder Dysfunction and Altered Somatic Sensitivity in PACAP −/− Mice

Bladder Dysfunction and Altered Somatic Sensitivity in PACAP ^−/− Mice