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Antithrombin is one of the main natural coagulation system inhibitors. It is potentiated by heparin, and may be a key component of heparin response, particularly in infants aged &lt;1 year. We sought to determine the impact of baseline antithrombin activity on response to heparin and thrombin generation during cardiopulmonary bypass (CPB).

Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity