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In clinical practice, reperfusion of ischemic myocardium usually occurs under high arterial oxygen levels. However, this might aggravate cardiac ischemia-reperfusion injury caused by excessive oxidative stress. In an experimental in vivo study, the cardioprotective role of hypoxic reoxygenation during initial reperfusion was assessed.

journal of thoracic and cardiovascular surgery

Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia–reperfusion injury after cardioplegic arrest in a porcine model