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We propose a simple model of pathologic microsatellite expansion, anddescribe an inherent self-repairing mechanism working against expansion. Weprove that if the probabilities of elementary expansions and contractions areequal, microsatellite expansions are always self-repairing. If theseprobabilities are different, self-reparation does not work. Mosaicism,anticipation and reverse mutation cases are discussed in the framework of themodel. We explain these phenomena and provide some theoretical evidence fortheir properties, for example the rarity of reverse mutations.

Simple Mathematical Model Of Pathologic Microsatellite Expansions: When Self-Reparation Does Not Work