English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

ObjectiveAdiponectin (ADPN), a recently discovered protein hormone, is exclusively expressed on and secreted from adipocyte. ADPN is a particularly interesting compound because it may have a protective influence on the cardiovascular system. This study was a prospective hospital based study aiming to evaluate ADPN serum level among children with nephrotic syndrome (NS), right ventricular functions by echocardiography and finding any correlation between ADPN as a protective hormone and right ventricular functions.Patients and methodsThe study included 47 patients (28 boys and 19 girls) with steroid responsive nephrotic syndrome (SRNS). Cases included two groups: Group A – included 25 patients with SRNS in relapse. Group B – included 22 patients with SRNS in remission for periods ranging from 3 to 9months and with no steroid therapy. In addition to control group which included 28 children with matched age and sex.MethodsA thorough history and full clinical examinations and echocardiography measuring right and left ventricular wall functions and other abnormalities if present were done. Blood samples were collected for measuring serum levels of total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) by enzymatic colorimetric kits, in addition to ADPN by ELISA method.ResultsSerum ADPN level was significantly higher in patients with SRNS in relapse (33.4±15.60μg/ml) in comparison with patients with SRNS in remission (12.54±8.76μg/ml) and with control group (10.54±6.43μg/ml) with P value <0.001 for both, we found a significant decrease in right ventricular ejection fraction (RVEF %) in patients with SRNS in relapse (57.9±4.5) in comparison to cases with SRNS in remission and control group (75.2±3.1 and 76.56±3.3), respectively.ConclusionsDuring relapse of SRNS, ADPN serum level is higher than its level in SRNS in remission and also, right ventricular strain occurs in relapsed SRNS may be due to haemodynamic overload. Good management of NS with wide scope of investigations aiming for detection and management of thrombolic and cardiovascular complications of NS is highly recommended

Adiponectin serum level among children with nephrotic syndrome in relation to right ventricular functions